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What is paroxetine
Buying paroxetine treats depression, panic attacks, obsessive-compulsive disorder (OCD), anxiety disorders, and post-traumatic stress disorder. It works by helping restore the balance of a natural chemical (serotonin) in the brain. Paroxetine is known as a selective serotonin reuptake inhibitor (SSRI).
This medication can improve your mood, sleep, appetite, and energy levels, and can help restore your interest in daily life. It can reduce anxiety, worry, unwanted thoughts, and the number of panic attacks. It can also reduce the urge to perform repetitive tasks (compulsions such as hand washing, counting, and checking) that disrupt daily life.
How to use paroxetine
Read the medication guide and, if available, the patient information leaflet provided by your pharmacist before you start taking paroxetine each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication orally with or without food as directed by your doctor, usually once daily in the morning. Taking this medication with food may reduce nausea. If this medication makes you drowsy during the day, talk to your doctor about taking it in the evening.
The dosage is based on your medical condition, response to treatment, age, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects, your doctor may start you on a low dose and gradually increase your dosage. Follow your doctor’s instructions carefully. Do not increase your dose or use this medication more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.
If you are taking Paroxetine for premenstrual problems, your doctor may advise you to take it every day of the month or only during the two weeks before your period, up to and including the first full day.
Continue taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor. Some conditions may worsen when this medication is suddenly stopped. You may also experience mood swings, headaches, fatigue, sleep changes, and fleeting feelings like electric shock. To prevent these symptoms while you are stopping treatment with this medication, your doctor may gradually reduce your dose. Consult your doctor or pharmacist for more information. Report any new or worsening symptoms immediately.
It may take several weeks before you get the full benefit of this medicine.
Tell your doctor if your condition does not improve or worsens.
Paroxetine side effects
Nausea, drowsiness, dizziness, trouble sleeping, loss of appetite, weakness, dry mouth, sweating, blurred vision, and yawning may occur. Tell your doctor or pharmacist immediately if any of these effects persist or worsen.
Remember, this medication has been prescribed because your doctor has determined that the benefit outweighs the risk of side effects. Many people who use this medication do not experience serious side effects.
Tell your doctor right away if you have any serious side effects, including: shaking (tremor), restlessness, inability to sit still, decreased interest in sex, changes in sexual ability, numbness/tingling, easy bleeding/bruising, fast/irregular heartbeat, muscle weakness/spasms, seizures.
Seek immediate medical attention if you have any serious side effects, including black stools, vomit that looks like coffee grounds, eye pain/swelling/redness, dilated pupils, or vision changes (such as seeing rainbows around lights at night).
This medication may increase serotonin levels and rarely cause a serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other medications that increase serotonin levels, so tell your doctor or pharmacist about all your medications. Seek immediate medical attention if you experience any of the following symptoms: rapid heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, muscle twitching, unexplained fever, unusual agitation/restlessness.
Rarely, men may experience a painful or prolonged erection lasting four hours or longer. If this happens, stop taking this medication and seek immediate medical attention, otherwise, permanent problems may occur.
A serious allergic reaction to this medication is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or difficulty breathing.
This is not a complete list of possible side effects. Talk to your doctor or pharmacist if you notice any side effects other than those listed above.
Precautionary measures
Before taking paroxetine, tell your doctor or pharmacist if you are allergic to it or have any other allergies. This product may contain inactive ingredients that can cause allergic reactions or other problems. Talk to your pharmacist for more information.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of bipolar/manic-depressive disorder, personal or family history of suicide attempts, liver problems, kidney problems, seizures, low sodium levels in the blood, bleeding problems, personal or family history of glaucoma (angle closure type).
This medication may make you dizzy or drowsy, or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, operate machinery, or do anything that requires alertness or clear vision until you can do so safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Older adults may be more sensitive to the side effects of this medication, especially bleeding or loss of coordination. They are also more likely to develop a form of salt imbalance (hyponatremia), especially if they also take “water pills” (diuretics). Loss of coordination can increase the risk of falls.
Children may be more sensitive to the side effects of this medication, especially loss of appetite and weight loss. Monitor the weight and height of children taking this medication.
This medication is not recommended for use during pregnancy. It may harm an unborn baby, and babies born to mothers who have used it during the last three months of pregnancy may sometimes have withdrawal symptoms such as feeding/breathing problems, seizures, muscle stiffness, or constant crying. Since untreated mental/mood problems (such as depression, panic attacks, obsessive-compulsive disorder, and anxiety) can harm both a pregnant woman and her unborn baby, do not stop taking this medication unless directed by your doctor. Instead, ask your doctor if another medication is right for you. If you are planning to become pregnant, become pregnant, or think you may be pregnant, tell your doctor right away.
This medication passes into breast milk. Consult your doctor before breastfeeding.
Paroxetine | Interactions
Drug interactions can change how your medications work or increase your risk of serious side effects. This document does not contain all possible drug interactions. Keep a list of all your products (including prescription and over-the-counter medications and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medications without your doctor’s approval.
Some products that may interact with this medicine include thioridazine, other medicines that may cause bleeding/bruising (including antiplatelet agents such as clopidogrel, NSAIDs such as ibuprofen/naproxen, “blood thinners” such as dabigatran/warfarin).
Aspirin can increase the risk of bleeding when used with this medication. For example, if your doctor has prescribed low-dose aspirin for heart attack or stroke prevention (usually 81-162 milligrams per day), you should continue taking it unless your doctor tells you otherwise. Ask your doctor or pharmacist for more information.
This medication can slow the removal of other medications from your body, which may affect how they work. Examples of affected medications include atomoxetine, phenothiazines, pimozide, risperidone, tamoxifen, tetrabenazine, antiarrhythmics such as propafenone/flecainide, and TCA antidepressants such as desipramine/amitriptyline.
Using MAOIs with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAOIs (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) while taking this medication. Most MAOIs should also not be taken for two weeks before and after treatment with this medication. Ask your doctor when you should start or stop taking this medication.
The risk of serotonin syndrome/toxicity increases if you also use other medications that increase serotonin levels. Examples include street drugs such as MDMA/ecstasy, St. John’s wort, certain antidepressants (including other SSRIs such as citalopram/fluoxetine, SNRIs such as duloxetine/venlafaxine), and tryptophan. The risk of serotonin syndrome/toxicity may be increased when you start or increase the dose of these medications.
Tell your doctor or pharmacist if you are taking other products that cause drowsiness, including alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and opioid pain relievers (such as codeine).
Check the labels on all your medications (such as allergy or cough and cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist how to use these products safely.
This medication may interfere with certain medical/laboratory tests (including brain scans for Parkinson’s disease), possibly causing false test results. Make sure laboratory personnel and all your doctors know you are taking this medication.
